The Spanish word 'mano' (meaning 'hand') comes directly from the Latin word 'manus', which meant both 'hand' and by extension 'power'. This is a straightforward inheritance from Latin to Spanish, with just a slight change in the ending from '-us' to '-o', which is a common pattern in Spanish words derived from Latin.

Many common Spanish words and expressions use 'mano', such as 'manojo' (handful), 'manual' (manual, handbook), and 'manita' (little hand). The word appears in many everyday phrases like 'dar una mano' (to give a hand, to help) and 'de segunda mano' (second-hand).

English has many words derived from the same Latin root 'manus'. Some common examples include 'manual' (done by hand), 'manage' (originally meaning to handle or control), 'manipulate' (to handle or control skillfully), 'manufacture' (literally 'to make by hand'), and 'maneuver' (originally referring to hand work). Even the word 'maintain' comes from Latin 'manu tenere' meaning 'to hold in the hand'.