The Spanish word 'mamado' comes from the verb 'mamar' (meaning 'to suckle') combined with the past participle suffix '-ado'. The verb 'mamar' itself derives from Latin 'mammāre', which also meant 'to suckle'. While the literal meaning of 'mamado' is 'suckled', it has developed a colloquial meaning of 'drunk' in modern Spanish. This semantic shift likely comes from the association between drinking alcohol and sucking liquid, similar to how a baby suckles milk.

Some related Spanish words include the verb 'mamar' (to suckle), 'mama' or 'mamá' (mom/mother), and 'mamífero' (mammal). All these words share the connection to maternal nursing and breast-feeding. While 'mamado' has taken on the slang meaning of 'drunk', these related words maintain their connection to the original meaning of nursing or motherhood.

English words related to 'mamado' include 'mammal', 'mammary', and 'mammoth'. These all derive from the same Latin root related to breasts and nursing. 'Mammal' specifically refers to animals that nurse their young with milk from mammary glands. The word 'mamma' is also sometimes used in English as an informal word for mother, similar to the Spanish 'mama'.